Metabolic Remodeling of Cell-Surface Sialic Acids: Principles, Applications, and Recent Advances

被引：104

作者：

Cheng, Bo ^{[1
,2
]}

Xie, Ran ^{[1
,2
]}

Dong, Lu ^{[1
,2
]}

Chen, Xing ^{[1
,2
]}

机构：

[1] Peking Univ, Synthet & Funct Biomolecules Ctr, Coll Chem & Mol Engn, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China

[2] Peking Univ, Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China

来源：

CHEMBIOCHEM | 2016年 / 17卷 / 01期

基金：

中国国家自然科学基金;

关键词：

bioorthogonal chemistry; chemical reporters; click chemistry; metabolic glycan labeling; sialic acids; ACYL SIDE-CHAIN; BIOORTHOGONAL CHEMICAL REPORTERS; N-ACETYLMANNOSAMINE ANALOGS; FREE CLICK CHEMISTRY; POLYSIALIC ACID; IN-VIVO; CROSS-LINKING; LIVING ANIMALS; D-MANNOSAMINE; CANCER-CELLS;

D O I：

10.1002/cbic.201500344

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cell-surface sialic acids are essential in mediating a variety of physiological and pathological processes. Sialic acid chemistry and biology remain challenging to investigate, demanding new tools for probing sialylation in living systems. The metabolic glycan labeling (MGL) strategy has emerged as an invaluable chemical biology tool that enables metabolic installation of useful functionalities into cell-surface sialoglycans by hijacking the sialic acid biosynthetic pathway. Here we review the principles of MGL and its applications in study and manipulation of sialic acid function, with an emphasis on recent advances.

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页码：11 / 27

页数：17

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