Sharing secrets: Oxytocin and trust in schizophrenia

被引：128

作者：

Keri, Szabolcs ^{[1
]}

Kiss, Imre ^{[1
]}

Kelemen, Oguz ^{[2
]}

机构：

[1] Semmelweis Univ, Dept Psychiat & Psychotherapy, H-1083 Budapest, Hungary

[2] Bacs Kiskun Cty Hosp, Kecskemet, Hungary

来源：

SOCIAL NEUROSCIENCE | 2009年 / 4卷 / 04期

关键词：

Schizophrenia; Oxytocin; Trust; Negative symptoms; CEREBROSPINAL-FLUID; REPEATABLE BATTERY; NEURAL CIRCUITRY; NEUROPSYCHOLOGICAL STATUS; SCREENING-TEST; VASOPRESSIN; ATTACHMENT; CORTISOL; NEUROPHYSINS; RESPONSES;

D O I：

10.1080/17470910802319710

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Previous studies indicated that oxytocin plays an important role in human trust, which is impaired in patients with severe mental disorders. In this study, we measured plasma oxytocin levels in patients with schizophrenia (n=50) and in healthy controls (n=50) after neutral and trust-related interpersonal interactions. Trust-related interactions were associated with increased oxytocin levels in controls. This effect was absent in patients with schizophrenia. Low oxytocin levels measured after trust-related interactions significantly predicted the negative symptoms of schizophrenia but were not related to positive symptoms, depression, anxiety, and neuropsychological functions. These results suggest that decreased trust-related oxytocin release is related to the negative symptoms and may be associated with social withdrawal, isolation, and flattened affect in schizophrenia.

引用

页码：287 / 293

页数：7

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