Survival signaling goes BAD

被引：75

作者：

Bergmann, A ^{[1
]}

机构：

[1] Univ Texas, MD Anderson Canc Ctr, Dept Biochem & Mol Biol, Houston, TX 77030 USA

来源：

DEVELOPMENTAL CELL | 2002年 / 3卷 / 05期

关键词：

D O I：

10.1016/S1534-5807(02)00328-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Work published in this issue of Developmental Cell demonstrates, in vivo, that the proapoptotic gene BAD provides a genetic link between the cell death machinery and survival signaling. This work has implications for development, tissue homeostasis, and tumorigenesis.

引用

页码：607 / 608

页数：2

共 9 条

[1] BCL-2, BCL-XL sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis
Cheng, EHYA
Wei, MC
Weiler, S
Flavell, RA
Mak, TW
Lindsten, T
Korsmeyer, SJ
[J]. MOLECULAR CELL, 2001, 8 (03) : 705 - 711
[2] Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis
Datta, SR
Ranger, AM
Lin, MZ
Sturgill, JF
Ma, YC
Cowan, CW
Dikkes, P
Korsmeyer, SJ
Greenberg, ME
[J]. DEVELOPMENTAL CELL, 2002, 3 (05) : 631 - 643
[3] Cellular survival: a play in three Akts
Datta, SR
Brunet, A
Greenberg, ME
[J]. GENES & DEVELOPMENT, 1999, 13 (22) : 2905 - 2927
[4] Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
Datta, SR
Dudek, H
Tao, X
Masters, S
Fu, HA
Gotoh, Y
Greenberg, ME
[J]. CELL, 1997, 91 (02) : 231 - 241
[5] DEL PL, 1997, SCIENCE, V278, P687
[6] Programmed cell death in animal development
Jacobson, MD
Weil, M
Raff, MC
[J]. CELL, 1997, 88 (03) : 347 - 354
[7] SOCIAL CONTROLS ON CELL-SURVIVAL AND CELL-DEATH
RAFF, MC
[J]. NATURE, 1992, 356 (6368) : 397 - 400
[8] Proapoptotic BAX and BAK: A requisite gateway to mitochondrial dysfunction and death
Wei, MC
Zong, WX
Cheng, EHY
Lindsten, T
Panoutsakopoulou, V
Ross, AJ
Roth, KA
MacCregor, GR
Thompson, CB
Korsmeyer, SJ
[J]. SCIENCE, 2001, 292 (5517) : 727 - 730
[9] Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BGL-X(L)
Zha, JP
Harada, H
Yang, E
Jockel, J
Korsmeyer, SJ
[J]. CELL, 1996, 87 (04) : 619 - 628

← 1 →