Spectrophotometric analysis of some phenothiazine neuroleptics using chloramine-T

被引：16

作者：

Basavaiah, K ^{[1
]}

Swamy, JM

Krishnamurthy, G

机构：

[1] Univ Mysore, Dept Chem, Mysore 570006, Karnataka, India

[2] PES Coll Sci, Dept Chem, Mandya 571401, India

来源：

ANALYTICAL LETTERS | 1999年 / 32卷 / 13期

关键词：

phenothiazine drugs; neuroleptics; chloramine-T; spectrophotometry; pharmaceutical preparations;

D O I：

10.1080/00032719908542992

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A sensitive and selective spectrophotometric method has been developed for the determination of six phenothiazine neuroleptics. The method is based on the interaction of the drugs with chloramine-T in sulphuric acid medium to yield a red reddish-violet, orange or greenish-blue intermediate with maximum absorption at 500-636 nm. Beer's law is obeyed over the range 5-125 mu g ml(-1) of the drugs. The apparent molar absorptivities were found to be in the range 1.04x10(3) to 5.46x10(3) l.mol(-1) cm(-1). The investigated drugs were assayed in tablets and injections. The mean percentage recoveries were 97.65-101.75 and the relative standard deviations were found to be less than 2%.

引用

页码：2613 / 2623

页数：11

共 32 条

[1]

ALPDOGAN GY, 1997, CHIM ACTA TURC, V25, P31

[2]

BURGOT JL, 1979, ANN PHARM FR, V37, P125

[3] SPECTROPHOTOMETRIC DETERMINATION OF SOME N-SUBSTITUTED PHENOTHIAZINE-DERIVATIVES USING N-BROMOPHTHALIMIDE [J].