Involvement of nigral glutamatergic inputs in the control of seizures in a genetic model of absence epilepsy in the rat

被引:72
作者
Deransart, C
Marescaux, C
Depaulis, A
机构
[1] Neurobiologie Neuropharmacologie E., INSERM U. 398, Faculté de Médecine, 67085 Strasbourg Cedex, 11, rue Humann
关键词
basal ganglia; substantia nigra pars reticulata; subthalamic nucleus; glutamate; NMDA; microinjection;
D O I
10.1016/0306-4522(95)00471-8
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The reticular part of the substantia nigra is known to be a critical site in the control of epileptic seizures. Potentiation of the direct striatonigral GABAergic projection has been shown to suppress seizures in different animal models of epilepsy. Besides this GABAergic input, the substantia nigra receives glutamatergic inputs, especially from the indirect striatonigral pathway, via the subthalamic nucleus. To investigate the involvement of the nigral excitatory amino acid transmission in the remote control of non-convulsive generalized seizures, several drugs interacting with glutamatergic receptors were first injected into the substantia nigra pars reticulata in rats with spontaneous absence seizures. Blockade of N-methyl-D-aspartate receptors suppressed spontaneous generalized non-convulsive seizures in the rat, whereas blockade of non-N-methyl-D-aspartate receptors was without effect. Second, inhibition of the subthalamic projection by bilateral injections of a GABAergic agonist in this structure similarly suppressed absence seizures. These results suggest that excitatory amino acid inputs are critical in the triggering of the nigral control of generalized epilepsies. Furthermore, they support the hypothesis of a possible involvement of the subthalamonigral pathway in the control of generalized non-convulsive seizures.
引用
收藏
页码:721 / 728
页数:8
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