Receptor-dependent coronavirus infection of dendritic cells

被引：18

作者：

Turner, BC

Hemmila, EM

Beauchemin, N

Holmes, KV

机构：

[1] Univ Colorado, Ctr Hlth Sci, Dept Microbiol, Denver, CO 80262 USA

[2] McGill Univ, McGill Canc Ctr, Montreal, PQ, Canada

[3] McGill Univ, Dept Biochem, Montreal, PQ, Canada

[4] McGill Univ, Dept Med, Montreal, PQ, Canada

[5] McGill Univ, Dept Oncol, Montreal, PQ, Canada

来源：

JOURNAL OF VIROLOGY | 2004年 / 78卷 / 10期

关键词：

D O I：

10.1128/JVI.78.10.5486-5490.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In several mammalian species, including humans, coronavirus infection can modulate the host immune response. We show a potential role of dendritic cells (DC) in murine coronavirus-induced immune modulation and pathogenesis by demonstrating that the JAW SII DC line and primary DC from BALB/c mice and p/p mice with reduced expression of the murine coronavirus receptor, murine CEACAM1a, are susceptible to murine coronavirus infection by a receptor-dependent pathway.

引用

页码：5486 / 5490

页数：5

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