Sentinel node biopsy as an indicator for pelvic nodes dissection in early stage cervical cancer

被引:46
作者
Rhim, CC [1 ]
Park, JS [1 ]
Bae, SN [1 ]
Namkoong, SE [1 ]
机构
[1] Catholic Univ Korea, Coll Med, Kangnam St Marys Hosp, Dept Obstet & Gynecol,Seocho Gu, Seoul 137040, South Korea
关键词
sentinel lymph node biopsy; cervix neoplasms;
D O I
10.3346/jkms.2002.17.4.507
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The purpose of this study was to investigate the feasibility of sentinel node frozen biopsy to minimize the extensive pelvic lymph nodes dissection in early stage cervical cancer patients on the basis that the risk of skip metastasis to the para-aortic area is negligible. Twenty-six patients with early stage cervical cancer were enrolled in this study. Technetium-99m colloid albumin (Tc-99m) was injected intradermally around the tumor for allowing preoperative lymphoscintigraphy and intraoperative hand-held gama probe detection of seninel nodes. For Visual detection, isosulfan blue dye was injected into the peritumoral sites before pleritoneal opening. Postoperative morbidity and negative predictive value were the endpoints of this study. The 26 patients, ranging in age from 32 to 71 yr, underwent intraoperative sentinel nodes mapping. All the patients underwent complete pelvic lymph nodes dissection including para-aortic nodes. There was one case with positive non-sentinel nodes despite the negative sentinel node by frozen biopsy (negative predictive value, 95.2%). This new technique of sentinel node mapping is safe and simple to perform. Further clinical trials using the combination of Tc-99m and isosulfan blue dye are warranted and this technique will make a true advance for less aggressive management of patients with early stage cervical cancer.
引用
收藏
页码:507 / 511
页数:5
相关论文
共 17 条
[1]   Historical perspective of lymphatic tumour spread and the emergence of the sentinel node concept [J].
Borgstein, P ;
Meijer, S .
EUROPEAN JOURNAL OF SURGICAL ONCOLOGY, 1998, 24 (02) :85-89
[2]  
CABANAS RM, 1977, CANCER, V39, P456, DOI 10.1002/1097-0142(197702)39:2<456::AID-CNCR2820390214>3.0.CO
[3]  
2-I
[4]   Guidelines for sentinel node biopsy and lymphatic mapping of patients with breast cancer [J].
Cox, CE ;
Pendas, S ;
Cox, JM ;
Joseph, E ;
Shons, AR ;
Yeatman, T ;
Ku, NN ;
Lyman, GH ;
Berman, C ;
Haddad, F ;
Reintgen, DS .
ANNALS OF SURGERY, 1998, 227 (05) :645-653
[5]  
Flett MM, 1998, BRIT J SURG, V85, P991
[6]   Sentinel lymphadenectomy in breast cancer [J].
Giuliano, AE ;
Jones, RC ;
Brennan, M ;
Statman, R .
JOURNAL OF CLINICAL ONCOLOGY, 1997, 15 (06) :2345-2350
[7]   LYMPHATIC MAPPING AND SENTINEL LYMPHADENECTOMY FOR BREAST-CANCER [J].
GIULIANO, AE ;
KIRGAN, DM ;
GUENTHER, JM ;
MORTON, DL .
ANNALS OF SURGERY, 1994, 220 (03) :391-401
[8]  
Gray H., 1918, ANATOMY HUMAN BODY
[9]   The sentinel node in breast cancer - A multicenter validation study [J].
Krag, D ;
Weaver, D ;
Ashikaga, T ;
Moffat, F ;
Klimberg, VS ;
Shriver, C ;
Feldman, S ;
Kusminsky, R ;
Gadd, M ;
Kuhn, J ;
Harlow, S ;
Beitsch, P .
NEW ENGLAND JOURNAL OF MEDICINE, 1998, 339 (14) :941-946
[10]   Class II versus class III radical hysterectomy in stage IB-IIA cervical cancer: A prospective randomized study [J].
Landoni, F ;
Maneo, A ;
Cormio, G ;
Perego, P ;
Milani, R ;
Caruso, O ;
Mangioni, C .
GYNECOLOGIC ONCOLOGY, 2001, 80 (01) :3-12