Dissociable concurrent activity of lateral and medial frontal lobe during negative feedback processing

被引:26
作者
Jimura, K [1 ]
Konishi, S [1 ]
Miyashita, Y [1 ]
机构
[1] Univ Tokyo, Sch Med, Dept Physiol, Bunkyo Ku, Tokyo 1130033, Japan
关键词
frontal lobe; negative feedback; cognition; emotion; fMRI;
D O I
10.1016/j.neuroimage.2004.04.012
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
External feedback on results of one's behavior guides flexible adaptation to changing environments. It has been suggested that the lateral and medial parts of the frontal lobe are responsible for cognitive and emotional functions, respectively. In the present fMRI study, multiple mental components evoked by the presentation of negative feedback were dissociated along the cognitive-emotional axis in set-shifting paradigms. The double dissociation of the concurrent feedback-related activity was observed in the right frontal lobe: the lateral frontal lobe was associated with the inferential component, whereas the medial frontal lobe was associated with the emotional component. However, among the multiple right lateral frontal regions, a region of interest (ROI) analysis indicated that the inferential component was not dominant in the region near the inferior frontal junction. The medial frontal activations were observed ventral and anterior to the presupplementary motor area, and dorsal and posterior to the anterior cingulate cortex. The double dissociation in the right frontal lobe suggests that the lateral and medial frontal lobe cooperatively but differentially contributes to the negative feedback processing, demonstrating the lateral-medial dichotomy of the frontal lobe functions suggested by previous neuropsychological studies. At the same time, the functional heterogeneity in the lateral and medial frontal lobe demands modifications of the traditional view of the functional organization of the frontal lobe. (C) 2004 Elsevier Inc. All rights reserved.
引用
收藏
页码:1578 / 1586
页数:9
相关论文
共 55 条
  • [1] [Anonymous], 1998, PREFRONTAL CORTEX EX
  • [2] Mapping the cingulate cortex in response selection and monitoring
    Badgaiyan, RD
    Posner, MI
    [J]. NEUROIMAGE, 1998, 7 (03) : 255 - 260
  • [3] RIGHT-HEMISPHERE SPECIALIZATION FOR THE IDENTIFICATION OF EMOTIONAL WORDS AND SENTENCES - EVIDENCE FROM STROKE PATIENTS
    BOROD, JC
    ANDELMAN, F
    OBLER, LK
    TWEEDY, JR
    WELKOWITZ, J
    [J]. NEUROPSYCHOLOGIA, 1992, 30 (09) : 827 - 844
  • [4] Anterior cingulate cortex and response conflict: Effects of frequency, inhibition and errors
    Braver, TS
    Barch, DM
    Gray, JR
    Molfese, DL
    Snyder, A
    [J]. CEREBRAL CORTEX, 2001, 11 (09) : 825 - 836
  • [5] Buckner RL, 2003, J NEUROSCI, V23, P3999
  • [6] Cognitive and emotional influences in anterior cingulate cortex
    Bush, G
    Luu, P
    Posner, MI
    [J]. TRENDS IN COGNITIVE SCIENCES, 2000, 4 (06) : 215 - 222
  • [7] Defining the neural mechanisms of probabilistic reversal learning using event-related functional magnetic resonance imaging
    Cools, R
    Clark, L
    Owen, AM
    Robbins, TW
    [J]. JOURNAL OF NEUROSCIENCE, 2002, 22 (11) : 4563 - 4567
  • [8] Prefrontal cortical contributions to working memory: evidence from event-related fMRI studies
    D'Esposito, M
    Postle, BR
    Rypma, B
    [J]. EXPERIMENTAL BRAIN RESEARCH, 2000, 133 (01) : 3 - 11
  • [9] THE RETURN OF GAGE,PHINEAS - CLUES ABOUT THE BRAIN FROM THE SKULL OF A FAMOUS PATIENT
    DAMASIO, H
    GRABOWSKI, T
    FRANK, R
    GALABURDA, AM
    DAMASIO, AR
    [J]. SCIENCE, 1994, 264 (5162) : 1102 - 1105
  • [10] LOCALIZATION OF A NEURAL SYSTEM FOR ERROR-DETECTION AND COMPENSATION
    DEHAENE, S
    POSNER, MI
    TUCKER, DM
    [J]. PSYCHOLOGICAL SCIENCE, 1994, 5 (05) : 303 - 305