Relative rates of nuclear DNA evolution in human and old world monkey lineages

被引:17
作者
Herbert, G [1 ]
Easteal, S [1 ]
机构
[1] AUSTRALIAN NATL UNIV,JOHN CURTIN SCH MED RES,HUMAN GENET GRP,CANBERRA,ACT 0200,AUSTRALIA
关键词
molecular clock; molecular evolution; substitution rate; primate; human; Old world monkey;
D O I
10.1093/oxfordjournals.molbev.a025656
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Rates of substitution were compared between humans and Old World monkeys for sequences in or adjacent to 19 genes. The comparison of 21,299 sites in noncoding regions indicates that the substitution rate is similar to 43% greater in the Old World monkey lineage. However, 83% of the compared sites are in the region of the beta-globin gene family. Outside this region there is no consistent pattern of rate difference between the two lineages. Comparison of the coding regions of 16 genomically dispersed genes, involving 1,592 synonymous sites and 5,275 nonsynonymous sites, showed a faster rate of substitution in the human lineage at the nonsynonymous sites of the prion gene, but otherwise no evidence of rate difference between the two lineages. It is concluded that rate differences between these two lineages may be specific to certain regions of the genome rather than being a general phenomenon. This conclusion needs to be confirmed by comparison of a larger number of genomically dispersed sequences. It is, however, consistent with the results of DNA-DNA hybridization experiments, which show no difference in evolutionary rate between the two lineages.
引用
收藏
页码:1054 / 1057
页数:4
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