Disturbances in the LIF pathway in the endometrium among women with unexplained infertility

被引:58
作者
Aghajanova, Lusine [1 ,2 ]
Altmae, Signe [2 ]
Bjuresten, Kerstin [2 ]
Hovatta, Outi [2 ]
Landgren, Britt-Marie [2 ]
Stavreus-Evers, Anneli [2 ,3 ]
机构
[1] Univ Calif San Francisco, Dept Obstet Gynecol & Reprod Sci, San Francisco, CA 94143 USA
[2] Karolinska Univ, Huddinge Hosp, Dept Clin Sci Intervent & Technol, Div Obstet & Gynecol,Karolinska Inst, Stockholm, Sweden
[3] Uppsala Univ, Dept Womens & Childrens Hlth, Uppsala, Sweden
基金
瑞典研究理事会;
关键词
LIF; LIFR; gp130; SOCS1; human endometrium; unexplained infertility; LEUKEMIA INHIBITORY FACTOR; IMPLANTATION WINDOW; PREIMPLANTATION EMBRYOS; RECEPTOR; EXPRESSION; PINOPODES; SECRETION; GP130; PROGESTERONE; RECEPTIVITY;
D O I
10.1016/j.fertnstert.2008.04.010
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: To study the expression of leukemia inhibitory factor (LIF), its receptors LIFR and up 130, and its inhibitor SOCS1 in endometria from fertile women and infertile women with unexplained infertility. Signaling through the LIF pathway is involved in maintenance of a receptive state of human endometrium. Impaired endometrial receptivity may be a cause of female infertility. Design: Prospective clinical study. Setting: Hospital-based IVF unit and university-affiliated reproductive research laboratories. Patient(s): Twenty-six healthy fertile women and 14 women with unexplained infertility. Intervention(s): Endometrial biopsy. Main Outcome Measure (s): Pinopode formation, expression of LIF, LIFR, up 130, and SOCS1 protein and m RNA in endometrial biopsies. Result(s): The expression of LIFR in the endometrium was negatively correlated to the expression of SOCS1 and positively correlated to the formation of pinopodes. In control fertile women, simultaneous intense apical staining of LIFR and up 130 together with faint SOCS1 staining was observed in epithelial cells, whereas the opposite was seen in most women with unexplained infertility. Conclusion(s): Unexplained infertility in some women might be explained by disturbances in the LIF pathway in midsecretory-phase endometrium. (Fertil Steril (R) 2009;91:2602-10. (c) 2009 by American Society for Reproductive Medicine.)
引用
收藏
页码:2602 / 2610
页数:9
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