Dopamine Modulates Effort-Based Decision Making in Rats

被引:141
作者
Bardgett, Mark E. [1 ]
Depenbrock, Melissa [1 ]
Downs, Nathan [1 ]
Points, Megan [1 ]
Green, Leonard [2 ]
机构
[1] No Kentucky Univ, Dept Psychol, Highland Hts, KY 41076 USA
[2] Univ Washington, Dept Psychol, Seattle, WA 98195 USA
关键词
choice behavior; T-maze; amphetamine; haloperidol; SCH-23390; NUCLEUS-ACCUMBENS DOPAMINE; MEDIAL FRONTAL-CORTEX; ANTERIOR CINGULATE; FOS EXPRESSION; LOCOMOTOR-ACTIVITY; D-2; RECEPTORS; D-AMPHETAMINE; STIMULATION; HALOPERIDOL; INVOLVEMENT;
D O I
10.1037/a0014625
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Previous research has implicated dopamine as a modulating factor in choice behavior based on effort. The purpose of the present study was to determine the individual contribution of different dopamine receptors to effort-based decision making in rats. Rats were trained in a T-maze to choose a large-reward arm that contained 8 pellets of food over a small-reward arm that contained 2 pellets of food. The rats then were trained to climb progressively higher barriers to obtain the food from the large-reward arm. Using a discounting procedure on each test day, it was found that rats were more likely to choose the small-reward arm after treatment with the D(1) antagonist, SCH-23390, or the D(2) antagonist, haloperidol. The dopamine agonist, D-amphetamine, biased the rats toward choosing the large-reward arm and blunted the effects of SCH-23390 or haloperidol. Treatment with the D(3) receptor antagonist, U99194, or the D(3) receptor agonist, 7-OH-DPAT, did not alter choice behavior. These data indicate that D(1) and D(2) receptors are required for decisions based on effort.
引用
收藏
页码:242 / 251
页数:10
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