Chronic excretion of a norovirus in a child with cartilage hair hypoplasia (CHH)

被引:66
作者
Gallimore, CI [1 ]
Lewis, D
Taylor, C
Cant, A
Gennery, A
Gray, JJ
机构
[1] Hlth Protect Agcy, Cent Publ Hlth Lab, Enteric Virus Unit, Enter Resp & Neurol Virus Lab, London, England
[2] Hlth Protect Agcy Yorkshire & Humber, Leeds Lab, Leeds, W Yorkshire, England
[3] Hlth Protect Agcy, Newcastle Lab, Newcastle Upon Tyne, Tyne & Wear, England
[4] Newcastle Gen Hosp, Newcastle Upon Tyne NE4 6BE, Tyne & Wear, England
关键词
norovirus; CHH; recombinant; BMT; T cell immunodeficiency;
D O I
10.1016/j.jcv.2003.10.007
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
We have demonstrated the long-term excretion of a stable recombinant norovirus in a patient with cartilage hair hypoplasia (CHH), with a T cell immunodeficiency, following bone marrow transplantation (BMT). The patient excreted an ARG320/1999/US-like recombinant norovirus (rGII-3) for 156 days during a period of immune reconstitution. The child was symptomatic during the period of virus shedding. It is not known if the child acquired the recombinant strain or if recombination occurred in vivo. (C) 2003 Elsevier B.V. All rights reserved.
引用
收藏
页码:196 / 204
页数:9
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