The transcription factor Sox11 is a prognostic factor for improved recurrence-free survival in epithelial ovarian cancer

被引：78

作者：

Brennana, Donal J. ^{[3
,4
]}

Ek, Sara ^{[1
,2
]}

Doyle, Emma ^{[3
,5
]}

Drew, Thomas ^{[3
,5
]}

Foley, Michael ^{[3
,5
]}

Flannelly, Grainne ^{[3
]}

O'Connor, Darran P. ^{[4
]}

Gallagher, William M. ^{[4
]}

Kilpinen, Sami ^{[6
]}

Kallioniemi, Olli-Pekka ^{[6
,7
]}

Jirstrom, Karin ^{[8
]}

O'Herlihy, Colm ^{[3
,5
]}

Borrebaeck, Carl A. K. ^{[1
,2
]}

机构：

[1] Lund Univ, Dept Immunotechnol, SE-22184 Lund, Sweden

[2] CREATE Hlth Ctr Translat Canc Res, BMC D13, SE-22184 Lund, Sweden

[3] Natl Matern Hosp, Dept Obstet & Gynaecol, Dublin 2, Ireland

[4] Univ Coll Dublin, Sch Biomol & Biomed Sci, Conway Inst, Dublin 2, Ireland

[5] Natl Matern Hosp, UCD Sch Med & Med Sci, Dublin 2, Ireland

[6] Univ Helsinki, Inst Mol Med Finland, FIMM, FIN-00014 Helsinki, Finland

[7] Univ Turku, SF-20500 Turku, Finland

[8] Lund Univ, Ctr Mol Pathol, Dept Lab Med, Malmo Univ Hosp, Malmo, Sweden

来源：

EUROPEAN JOURNAL OF CANCER | 2009年 / 45卷 / 08期

关键词：

Sox11; Epithelial ovarian cancer; Prognosis; Automated analysis; MANTLE CELL LYMPHOMA; BREAST-CANCER; EXPRESSION; GENE; BOX; PROTEINS; ROLES; MOUSE;

D O I：

10.1016/j.ejca.2009.01.028

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Current prognostic molecular markers for epithelial ovarian cancer (EOC) are insufficient. The aim of the current study was to investigate the role of Sox11 in EOC. Methods: Using an in silico transcriptomic screen, Sox11 was identified as a potential EOC biomarker. Sox11 protein expression was evaluated using immunohistochemistry (IHC) in 76 EOC cases, which were analysed using automated algorithms to develop a quantitative scoring model. Results: Sox11 mRNA expression was upregulated in EOC compared to normal tissues. Automated analysis of Sox11 in the EOC cohort revealed high expression of Sox11, in 40% of tumours, who had an improved recurrence-free survival (RFS) (p = 0.002). Multivariate analysis confirmed that Sox11 was an independent predictor of improved RFS after controlling for stage and grade. Conclusions: These data suggest that Sox11 is a new prognostic marker in EOC. Loss of Sox11 is associated with a decreased RFS and a more aggressive phenotype. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：1510 / 1517

页数：8

共 27 条

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