Twenty years of ageing research at the Mill Hill laboratories

Research on ageing was carried out in the Genetics Division laboratories, Mill Hill, London, from 1970 to 1990, resulting in more than 100 publications. The work centred around the in vitro ageing of human diploid fibroblasts, but there was also research on transformed cells, rat and mouse tissues, human lymphocytes, chick cells, mice and a microbial model system. The major conclusion from all this research, together with a broad overview of the whole field of gerontology, is that ageing has multiple causes, and that adult animals become senescent through the eventual failure of several important maintenance mechanisms. (C) 2002 Elsevier Science Inc. All rights reserved.