Sleep and Psychoneuroimmunology

被引:38
作者
Opp, Mark R. [1 ,2 ,3 ]
机构
[1] Univ Michigan, Dept Anesthesiol, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Dept Mol & Integrat Physiol, Ann Arbor, MI 48109 USA
[3] Univ Michigan, Grad Program Neurosci, Ann Arbor, MI 48109 USA
基金
美国国家卫生研究院;
关键词
Cytokine; Interleukin-1; Tumor necrosis factor; Fever; SLOW-WAVE SLEEP; MESSENGER-RNA EXPRESSION; INFLUENZA-VIRUS INFECTION; DIPEPTIDE-INDUCED SLEEP; NECROSIS-FACTOR-ALPHA; EYE-MOVEMENT SLEEP; PROMOTING FACTOR-S; CEREBROSPINAL-FLUID; INTERLEUKIN-1-INDUCED SLEEP; ENCEPHALITIS LETHARGICA;
D O I
10.1016/j.iac.2009.02.009
中图分类号
R392 [医学免疫学];
学科分类号
100108 [医学免疫学];
摘要
The brain uses a variety of mechanisms to survey the immune system constantly. Responses of the immune system to invading pathogens are detected by the central nervous system, which responds by orchestrating complex changes in behavior and physiology. Sleep is one of the behaviors altered in response to immune challenge. The role of cytokines as mediators of responses to infectious challenge and regulators and modulators of sleep is the focus of this article.
引用
收藏
页码:295 / +
页数:15
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