Tilting toward immunosuppression

被引：449

作者：

Hotchkiss, Richard S. ^{[1
,2
]}

Coopersmith, Craig M. ^{[1
,3
]}

McDunn, Jonathan E. ^{[1
]}

Ferguson, Thomas A. ^{[4
]}

机构：

[1] Washington Univ, Sch Med, Dept Anesthesiol, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Dept Med & Surg, St Louis, MO 63110 USA

[3] Washington Univ, Sch Med, Dept Surg, St Louis, MO 63110 USA

[4] Washington Univ, Sch Med, Dept Ophthalmol, St Louis, MO 63110 USA

来源：

NATURE MEDICINE | 2009年 / 15卷 / 05期

关键词：

SEPSIS; APOPTOSIS;

D O I：

10.1038/nm0509-496

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The immune response goes haywire during sepsis, a deadly condition triggered by infection. Richard S. Hotchkiss and his colleagues take the focus off of the prevailing view that the key aspect of this response is an exuberant inflammatory reaction. They assess recent human studies bolstering the notion that immunosuppression is also a major contributor to the disease. Many people with sepsis succumb to cardiac dysfunction, a process examined by Peter Ward. He showcases the factors that cause cardiomyocyte contractility to wane during the disease.

引用

页码：496 / 497

页数：2

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