Flow cytometric analysis of normal and neoplastic mast cells:: Role in diagnosis and follow-up of mast cell disease

被引：42

作者：

Escribano, Luis

Montero, Andres C. Garcia

Nunez, Rosa

Orfao, Alberto

机构：

[1] Hosp Ramon & Cajal, Hematol Serv, Dept Hematol, Mast Cell Unit, E-28034 Madrid, Spain

[2] Univ Salamanca, Ctr Canc Res, E-37008 Salamanca, Spain

[3] Univ Salamanca, Cytometry Serv, Ctr Invest Canc, E-37007 Salamanca, Spain

来源：

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA | 2006年 / 26卷 / 03期

关键词：

D O I：

10.1016/j.iac.2006.05.008

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Human mast cells (MCs) are directly derived from human pluripotent CD34+ stem and progenitor hematopoietic cells, with stem cell factor being a critical growth factor supporting human MC proliferation, differentiation, and survival. Because of the advantages that flow cytometry offers (it allows rapid, objective, and sensitive multiparameter analysis of high numbers of cells from a sample, with information being provided on the basis of a single cell), it has become the method of choice in the past decade for immunophenotypic identification, enumeration, and characterization of human MCs in bone marrow and other tissue specimens.

引用

页码：535 / +

页数：15

共 60 条

[1] A novel form of mastocytosis associated with a transmembrane c-kit mutation and response to imatinib [J].