Expression of Stem Cell Pluripotency Factors During Regeneration in Newts

被引：101

作者：

Maki, Nobuyasu ^{[1
,2
]}

Suetsugu-Maki, Rinako ^{[1
,2
]}

Tarui, Hiroshi ^{[3
]}

Agata, Kiyokazu ^{[4
]}

Del Rio-Tsonis, Katia ^{[5
]}

Tsonis, Panagiotis A. ^{[1
,2
]}

机构：

[1] Univ Dayton, Dept Biol, Dayton, OH 45469 USA

[2] Univ Dayton, Ctr Tissue Regenerat & Engn Dayton, Dayton, OH 45469 USA

[3] Ctr Dev Biol, RIKEN, Kobe, Hyogo, Japan

[4] Kyoto Univ, Dept Biophys, Kyoto, Japan

[5] Miami Univ, Dept Zool, Oxford, OH 45056 USA

来源：

DEVELOPMENTAL DYNAMICS | 2009年 / 238卷 / 06期

关键词：

newt regeneration; transdifferentiation; stem cell; pluripotency factors; LENS; FIBROBLASTS; INDUCTION;

D O I：

10.1002/dvdy.21959

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

In this study, we present data indicating that mammalian stem cell pluripotency-inducing factors are expressed during lens and limb regeneration in newts. The apparent expression even in intact tissues and the ensued regulation during regeneration raises the possibility that these factors might regulate tissue-specific reprogramming and regeneration. Furthermore, these factors should enable us to understand the similarities and differences between animal regeneration in the newt and stem cell strategies in mammals. Developmental Dynamics 238:1613-1616, 2009. (C) 2009 Wiley-Liss, Inc.

引用

页码：1613 / 1616

页数：4

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