Genetic diversity of the dnaJ gene in the Mycobacterium avium complex

被引：20

作者：

Morita, Y ^{[1
]}

Maruyama, S

Kabeya, H

Nagai, A

Kozawa, K

Kato, M

Nakajima, T

Mikami, T

Katsube, Y

Kimura, H

机构：

[1] Gunma Prefectural Inst Publ Hlth & Environm Sci, Maebashi, Gumma, Japan

[2] Nihon Univ, Coll Bioresource Sci, Dept Vet Med, Lab Vet Publ Hlth, Fujisawa, Kanagawa, Japan

[3] Gunma Univ, Sch Med, Dept Pediat, Maebashi, Gumma 371, Japan

[4] Takasaki Univ Hlth & Welf, Lab Food Microbiol & Hyg, Takasaki, Gumma, Japan

来源：

JOURNAL OF MEDICAL MICROBIOLOGY | 2004年 / 53卷 / 08期

关键词：

D O I：

10.1099/jmm.0.45601-0

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The Mycobacterium avium complex (MAC) is associated with various diseases in humans as a zoonosis. The dnaJ gene was partially sequenced in Schaefer's 28 reference strains of MAC, 14 human MAC isolates and 22 veterinary isolates. From substitutions affecting 21-32 nucleotides, all strains could be classified into 14 groups. Most nucleotide substitutions did not alter amino acid sequences. Approximately 8 % genetic diversity was seen in these strains, which divided into two clusters: cluster 1 (0.8 % genetic diversity), comprising the reference strain serotypes 1-6, 8-11 and 21 and all isolates; and cluster 11 (7 % genetic diversity), comprising the remaining reference strains. Analysis of the dnaJ gene in MAC may be useful in epidemiological studies.

引用

页码：813 / 817

页数：5

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