Lipid-lowering medication and risk of injury

被引：1

作者：

Bovbjerg, VE

Siscovick, DS

Psaty, BM

McCann, BS

Koepsell, TD

Raghunathan, TE

Wagner, EH

机构：

[1] Virginia Commonwealth Univ, Dept Internal Med, Richmond, VA 23298 USA

[2] Virginia Commonwealth Univ, Dept Biostat, Richmond, VA 23298 USA

[3] Virginia Commonwealth Univ, Dept Hlth Adm, Richmond, VA 23298 USA

[4] Univ Washington, Dept Med, Seattle, WA USA

[5] Univ Washington, Dept Hlth Serv, Seattle, WA 98195 USA

[6] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA

[7] Univ Michigan, Inst Social Res, Ann Arbor, MI 48109 USA

[8] Grp Hlth Cooperat Puget Sound, Ctr Hlth Studies, Seattle, WA USA

来源：

JOURNAL OF CLINICAL EPIDEMIOLOGY | 1999年 / 52卷 / 12期

关键词：

anticholesterolemic agents; cholesterol; lipoproteins; injury; coronary disease; case-control study;

D O I：

10.1016/S0895-4356(99)00125-0

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Meta-analyses of early primary prevention trials of lipid-lowering therapies suggested increased risk of injury deaths among treated persons. Our population-based case-control study examined the association of lipid-lowering medication use with fatal and nonfatal injuries in 298 cases and 332 controls. No increased injury risk was observed among current (OR = 0.46, 95% CI 0.18-1.21) or past users (OR = .92, 95% CI 0.44-1.95), after adjustment for behavioral disorders, medical conditions, and health status. Stratified analyses did not reveal sub-groups at significantly increased risk. These results, consistent with recent clinical trials and meta-analyses, suggest no increased injury risk associated with lipid-lowering medications. (C) Elsevier Science, Inc.

引用

页码：1197 / 1200

页数：4

共 11 条

[1] THE ASSOCIATION BETWEEN CHOLESTEROL AND DEATH FROM INJURY [J].