Dietary Intake of Fruits and Vegetables Improves Microvascular Function in Hypertensive Subjects in a Dose-Dependent Manner

被引:109
作者
McCall, Damian O. [1 ]
McGartland, Claire P. [1 ]
McKinley, Michelle C. [1 ]
Patterson, Chris C. [2 ]
Sharpe, Peter
McCance, David R. [3 ]
Young, Ian S. [1 ]
Woodside, Jayne V. [1 ]
机构
[1] Queens Univ Belfast, Nutr & Metab Grp, Ctr Publ Hlth, Belfast BT12 6BJ, Antrim, North Ireland
[2] Queens Univ Belfast, Dept Epidemiol & Publ Hlth, Ctr Publ Hlth, Belfast BT12 6BJ, Antrim, North Ireland
[3] Royal Victoria Hosp, Reg Ctr Endocrinol & Diabet, Belfast BT12 6BA, Antrim, North Ireland
关键词
acetylcholine; endothelium; hypertension; nutrition; AMERICAN-HEART-ASSOCIATION; ORAL VITAMIN-C; ENDOTHELIAL DYSFUNCTION; BLOOD-PRESSURE; STATEMENT; DISEASE; RISK; METAANALYSIS; CONSUMPTION; PREVENTION;
D O I
10.1161/CIRCULATIONAHA.108.831297
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background - Observational evidence has consistently linked increased fruit and vegetable consumption with reduced cardiovascular morbidity; however, there is little direct trial evidence to support the concept that fruit and vegetable consumption improves vascular function. This study assessed the dose-dependent effects of a fruit and vegetable intervention on arterial health in subjects with hypertension. Methods and Results-After a 4-week run-in period during which fruit and vegetable intake was limited to 1 portion per day, participants were randomized to consume either 1, 3, or 6 portions daily for the next 8 weeks. Endothelium-dependent and -independent arterial vasodilator responses were assessed by venous occlusion plethysmography in the brachial circulation before and after intervention. Compliance was monitored with serial contemporaneous 4-day food records and by measuring concentrations of circulating dietary biomarkers. A total of 117 volunteers completed the 12-week study. Participants in the 1-, 3-, and 6-portions/d groups reported consuming on average 1.1, 3.2, and 5.6 portions of fruit and vegetables, respectively, and serum concentrations of lutein and beta-cryptoxanthin increased across the groups in a dose-dependent manner. For each 1- portion increase in reported fruit and vegetable consumption, there was a 6.2% improvement in forearm blood flow responses to intra-arterial administration of the endothelium-dependent vasodilator acetylcholine (P=0.03). There was no association between increased fruit and vegetable consumption and vasodilator responses to sodium nitroprusside, an endothelium-independent vasodilator. Conclusions - The present study illustrates that among hypertensive volunteers, increased fruit and vegetable consumption produces significant improvements in an established marker of endothelial function and cardiovascular prognosis. (Circulation. 2009;119:2153-2160.)
引用
收藏
页码:2153 / 2160
页数:8
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