CD6-ligand interactions: a paradigm for SRCR domain function?

被引：133

作者：

Aruffo, A

Bowen, MA

Patel, DD

Haynes, BF

Starling, GC

Gebe, JA

Bajorath, J

机构：

[1] DUKE UNIV,SCH MED,DEPT MED,DURHAM,NC 27710

[2] UNIV WASHINGTON,DEPT BIOL STRUCT,SEATTLE,WA 98195

来源：

IMMUNOLOGY TODAY | 1997年 / 18卷 / 10期

关键词：

D O I：

10.1016/S0167-5699(97)01130-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The scavenger receptor cysteine-rich (SRCR) superfamily, which includes proteins expressed by leukocytes, can be subdivided into groups A and B. Group B contains the lymphocyte cell-surface receptor CD6. This article reviews recent progress in understanding the interaction between CD6 and its ligand, activated leukocyte cell adhesion molecule (ALCAM). Analysis of the CD6-ALCAM interaction may help to understand how other SRCR domains bind to their ligands.

引用

页码：498 / 504

页数：7

共 44 条

[1] THE LYMPHOCYTE GLYCOPROTEIN-CD6 CONTAINS A REPEATED DOMAIN-STRUCTURE CHARACTERISTIC OF A NEW FAMILY OF CELL-SURFACE AND SECRETED PROTEINS
ARUFFO, A
MELNICK, MB
LINSLEY, PS
SEED, B
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1991, 174 (04) : 949 - 952
[2] MOLECULAR-MODEL OF THE N-TERMINAL RECEPTOR-BINDING DOMAIN OF THE HUMAN CD6 LIGAND ALCAM
BAJORATH, J
BOWEN, MA
ARUFFO, A
[J]. PROTEIN SCIENCE, 1995, 4 (08) : 1644 - 1647
[3] Identification of a novel inducible cell-surface ligand of CD5 on activated lymphocytes
Biancone, L
Bowen, MA
Lim, A
Aruffo, A
Andres, G
Stamenkovic, I
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 184 (03) : 811 - 819
[4] Identification of residues in CD6 which are critical for ligand binding
Bodian, DL
Skonier, JE
Bowen, MA
Neubauer, M
Siadak, AW
Aruffo, A
Bajorath, J
[J]. BIOCHEMISTRY, 1997, 36 (09) : 2637 - 2641
[5] BOTT CM, 1993, INT IMMUNOL, V7, P783
[6] Bowen MA, 1997, J IMMUNOL, V158, P1149
[7] The amino-terminal immunoglobulin-like domain of activated leukocyte cell adhesion molecule binds specifically to the membrane-proximal scavenger receptor cysteine-rich domain of CD6 with a 1:1 stoichiometry
Bowen, MA
Bajorath, J
Siadak, AW
Modrell, B
Malacko, AR
Marquardt, H
Nadler, SG
Aruffo, A
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (29) : 17390 - 17396
[8] CLONING, MAPPING, AND CHARACTERIZATION OF ACTIVATED LEUKOCYTE-CELL ADHESION MOLECULE (ALCAM), A CD6 LIGAND
BOWEN, MA
PATEL, DD
LI, X
MODRELL, B
MALACKO, AR
WANG, WC
MARQUARDT, H
NEUBAUER, M
PESANDO, JM
FRANCKE, U
HAYNES, BF
ARUFFO, A
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 181 (06) : 2213 - 2220
[9] BOWEN MA, IN PRESS EUR J IMMUN
[10] CAMPBELL IG, 1994, CANCER RES, V54, P5761

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