The galactosyltransferase family

被引：167

作者：

Hennet, T ^{[1
]}

机构：

[1] Univ Zurich, Inst Physiol, CH-8057 Zurich, Switzerland

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2002年 / 59卷 / 07期

关键词：

glycosylation; galactose; enzyme; Golgi; cell biology; gene family;

D O I：

10.1007/s00018-002-8489-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Galactose is transferred via several linkages to acceptor structures by galactosyltransferase enzymes. In prokaryotes, galactose is mainly found on lipopolysaccharides and capsular polysaccharides. In eukaryotes, galactosyltransferases, which are localized in the Golgi apparatus, are involved in the formation of several classes of glycoconjugates and in lactose biosynthesis. Although they sometimes catalyze identical reactions, prokaryotic and eukaryotic galactosyltransferases share only little structural similarities. In mammals, 19 distinct galactosyltransferase enzymes have been characterized to date. These enzymes catalyze the transfer of galactose via beta1-4, beta1-3, alpha1-3 and alpha1-4 linkages. The present review focuses on the description of these mammalian galactosyltransferases.

引用

收藏

页码：1081 / 1095

页数：15

相关论文

共 128 条

[1]

Allen AC, 1999, J AM SOC NEPHROL, V10, P1763

[2] Cloning and expression of a proteoglycan UDP-galactose:β-xylose β1,4-galactosyltransferase I -: A seventh member of the human β4-galactosyltransferase gene family [J].

Almeida, R ;

Levery, SB ;

Mandel, U ;

Kresse, H ;

Schwientek, T ;

Bennett, EP ;

Clausen, H .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (37) :26165-26171

[3] A family of human β4-galactosyltransferases -: Cloning and expression of two novel UDP-galactose:: β-N-acetylglucosamine β1,4-galactosyltransferases, β4Gal-T2 and β4Gal-T3 [J].

Almeida, R ;

Amado, M ;

David, L ;

Levery, SB ;

Holmes, EH ;

Merkx, G ;

van Kessel, AG ;

Rygaard, E ;

Hassan, H ;

Bennett, E ;

Clausen, H .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (51) :31979-31991

[4] ISSUES IN SEARCHING MOLECULAR SEQUENCE DATABASES [J].

ALTSCHUL, SF ;

BOGUSKI, MS ;

GISH, W ;

WOOTTON, JC .

NATURE GENETICS, 1994, 6 (02) :119-129

[5] A family of human β3-galactosyltransferases -: Characterization of four members of a UDP-galactose:β-N-acetyl-glucosamine/βN-acetyl-galactosamine β-1,3-galactosyltransferase family [J].

Amado, M ;

Almeida, R ;

Carneiro, F ;

Levery, SB ;

Holmes, EH ;

Nomoto, M ;

Hollingsworth, MA ;

Hassan, H ;

Schwientek, T ;

Nielsen, PA ;

Bennett, EP ;

Clausen, H .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (21) :12770-12778

[6] Growth retardation and early death of beta-1,4-galactosyltransferase knockout mice with augmented proliferation and abnormal differentiation of epithelial cells [J].

Asano, M ;

Furukawa, K ;

Kido, M ;

Matsumoto, S ;

Umesaki, Y ;

Kochibe, N ;

Iwakura, Y .

EMBO JOURNAL, 1997, 16 (08) :1850-1857

[7] Two types of MGDG synthase genes, found widely in both 16:3 and 18:3 plants, differentially mediate galactolipid syntheses in photosynthetic and nonphotosynthetic tissues in Arabidopsis thaliana [J].

Awai, K ;

Maréchal, E ;

Block, MA ;

Brun, D ;

Masuda, T ;

Shimada, H ;

Takamiya, K ;

Ohta, H ;

Joyard, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (19) :10960-10965

[8] Biosynthesis of the linkage region of glycosaminoglycans -: Cloning and activity of galactosyltransferase II, the sixth member of the β1,3-galactosyltransferase family (β3GalT6) [J].

Bai, XM ;

Zhou, DP ;

Brown, JR ;

Crawford, BE ;

Hennet, T ;

Esko, JD .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (51) :48189-48195

[9]

BAKKER H, 1994, J BIOL CHEM, V269, P30326

[10] PERMANENT MIXED-FIELD POLYAGGLUTINABLE ERYTHROCYTES LACK GALACTOSYLTRANSFERASE ACTIVITY [J].

BERGER, EG ;

KOZDROWSKI, I .

FEBS LETTERS, 1978, 93 (01) :105-108

← 1 2 3 4 5 6 7 8 9 10 →