How do Parkin mutations result in neurodegeneration?

被引：44

作者：

Imai, Y ^{[1
]}

Takahashi, R ^{[1
]}

机构：

[1] RIKEN, Brain Sci Inst, Motor Syst Neurodegenerat, Wako, Saitama 3510198, Japan

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2004年 / 14卷 / 03期

关键词：

D O I：

10.1016/j.conb.2004.04.002

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The gene product responsible for autosomal recessive juvenile Parkinsonism, Parkin, has been observed to have ubiquitin ligase activity. This finding has changed the direction of studies on Parkinson's disease by suggesting that abnormal protein turnover might be involved in its pathogenesis. A number of potentially neurotoxic Parkin-specific substrates have been identified. Further investigation of Parkin knockout mice will hopefully provide new evidence in the search for Parkin's substrates and further clarify their role in Parkinson's disease.

引用

页码：384 / 389

页数：6

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