Endostatin's endpoints-deciphering the endostatin antiangiogenic pathway

被引：31

作者：

Benezra, R

Rafii, S

机构：

[1] Mem Sloan Kettering Canc Ctr, Canc Biol & Genet Program, New York, NY 10021 USA

[2] Cornell Univ, Coll Med, Dept Med Genet, New York, NY 10021 USA

来源：

CANCER CELL | 2004年 / 5卷 / 03期

关键词：

D O I：

10.1016/S1535-6108(04)00057-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Up until now, the precise mechanism for endostatin's antiangiogenesis action was not known. In a recent report, Abdollahi et al. (2004) have taken advantage of gene array and proteomic analysis to map the antiangiogenic pathways turned on by endostatin. This study resolves some of the controversies surrounding endostatin's biology, and provides a new direction to help dissect the molecular pathways involved in endostatin's selective tumor antiangiogenic effects.

引用

页码：205 / 206

页数：2

共 11 条

[1] Endostatin's antiangiogenic signaling network
Abdollahi, A
Hahnfeldt, P
Maercker, C
Gröne, HJ
Debus, J
Ansorge, W
Folkman, J
Hlatky, L
Huber, PE
[J]. MOLECULAR CELL, 2004, 13 (05) : 649 - 663
[2] Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance
Boehm, T
Folkman, J
Browder, T
OReilly, MS
[J]. NATURE, 1997, 390 (6658) : 404 - 407
[3] Thrombospondins as matricellular modulators of cell function
Bornstein, P
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2001, 107 (08) : 929 - 934
[4] Lack of antitumor activity of recombinant endostatin in a human neuroblastoma xenograft model
Jouanneau, E
Alberti, L
Nejjari, M
Treilleux, I
Vilgrain, I
Duc, A
Combaret, V
Favrot, M
Leboulch, P
Bachelot, T
[J]. JOURNAL OF NEURO-ONCOLOGY, 2001, 51 (01) : 11 - 18
[5] Cell surface glypicans are low-affinity endostatin receptors
Karumanchi, SA
Jha, V
Ramchandran, R
Karihaloo, A
Tsiokas, L
Chan, BD
Dhanabal, M
Hanai, J
Venkataraman, G
Shriver, Z
Keiser, N
Kalluri, R
Zeng, HY
Mukhopadhyay, D
Chen, RL
Lander, AD
Hagihara, K
Yamaguchi, Y
Sasisekharan, R
Cantley, L
Sukhatme, VP
[J]. MOLECULAR CELL, 2001, 7 (04) : 811 - 822
[6] α5β1 integrin activates an NF-κB-dependent program of gene expression important for angiogenesis and inflammation
Klein, S
de Fougerolles, AR
Blaikie, P
Khan, L
Pepe, A
Green, CD
Koteliansky, V
Giancotti, FG
[J]. MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (16) : 5912 - 5922
[7] Thrombospondin-1 as an endogenous inhibitor of angiogenesis and tumor growth
Lawler, J
[J]. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2002, 6 (01) : 1 - 12
[8] Id proteins in development, cell cycle and cancer
Ruzinova, MB
Benezra, R
[J]. TRENDS IN CELL BIOLOGY, 2003, 13 (08) : 410 - 418
[9] Effect of angiogenesis inhibition by Id loss and the contribution of bone-marrow-derived endothelial cells in spontaneous murine tumors
Ruzinova, MB
Schoer, RA
Gerald, W
Egan, JE
Pandolfi, PP
Rafii, S
Manova, K
Mittal, V
Benezra, R
[J]. CANCER CELL, 2003, 4 (04) : 277 - 289
[10] Id2 regulates angiogenesis through transcriptional repression of thrombospondin-1
Volpert, OV
Pili, R
Sikder, HA
Nelius, T
Zaichuk, T
Morris, C
Shiflett, CB
Devlin, MK
Conant, K
Alani, RM
[J]. CANCER CELL, 2002, 2 (06) : 473 - 483

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