Low frequency of FLT3 gene internal tandem duplication and activating loop mutation in therapy-related acute myelocytic leukemia and myelodysplastic syndrome

被引：12

作者：

Au, WY

Fung, AT

Ma, ES

Liang, RH

Kwong, YL

机构：

[1] Univ Hong Kong, Queen Mary Hosp, Dept Med, Hong Kong, Hong Kong, Peoples R China

[2] Univ Hong Kong, Queen Mary Hosp, Dept Pathol, Hong Kong, Hong Kong, Peoples R China

来源：

CANCER GENETICS AND CYTOGENETICS | 2004年 / 149卷 / 02期

关键词：

D O I：

10.1016/j.cancergencyto.2003.07.007

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

FLT3 gene internal tandem duplication (ITD) and activating loop mutations (13835) were determined in 22 cases of therapy-related acute myelocytic leukemia/myelodysplastic syndrome (t-AML/MDS) and 102 cases of de novo AML/MDS. In t-AML/MDS, FLT3 ITD was absent, and D835 was found in only one case of therapy-related acute promyelocytic leukemia (APL). In de novo AML/MDS, however, FLT3 ITD and D835 were significantly more frequent (28 of 102 cases, P = 0.024) and were associated with high peripheral blood and marrow blast counts. Our results suggest that different pathogenetic pathways might be involved in t-AML/MDS and de novo AML/MDS. (C) 2004 Elsevier Inc. All rights reserved.

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页码：169 / 172

页数：4

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