Improvements in aldol reactions with diketopiperazines

被引：19

作者：

González, JF ^{[1
]}

de la Cuesta, E ^{[1
]}

Avendaño, C ^{[1
]}

机构：

[1] Univ Complutense, Fac Farm, Dept Quim Organ & Farmaceut, E-28040 Madrid, Spain

来源：

SYNTHETIC COMMUNICATIONS | 2004年 / 34卷 / 09期

关键词：

aldol reaction; diketopiperazines; ortho-directed lithiation;

D O I：

10.1081/SCC-120030746

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Precipitation of products by using dichloromethane as solvent permits an efficient aldol-type reaction between 1,4-diacetyl-2,5-piperazinedione and aromatic aldehydes catalyzed by K'BuO/'BuOH independently of the electrophilic character of the aryl ring. A simple method to obtain 3-methyl-2,4,5-trimethoxybenzaldehyde is also reported.

引用

页码：1589 / 1597

页数：9

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