The Rel family of eukaryotic transcription factor

被引：43

作者：

Chytil, M

Verdine, GL

机构：

[1] Dept. of Chem. and Chemical Biology, Harvard University, Cambridge, MA 02138

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1996年 / 6卷 / 01期

关键词：

D O I：

10.1016/S0959-440X(96)80100-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Members of the Rel transcription factor family mediate the response of eukaryotic cells to a broad range of environmental treats, in addition to serving an essential role in the development of certain vertebrate and insect cells. It is now apparent that there are two classes of Rel proteins, which differ in whether they bind DNA as monomers or dimers and which use markedly different mechanisms to transduce intracellular signals. Recent progress has been made towards understanding the structural basis for the fascinating biology of these proteins.

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页码：91 / 100

页数：10

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