A review of the MHC genetics of rheumatoid arthritis

被引：175

作者：

Newton, JL ^{[1
]}

Harney, SMJ ^{[1
]}

Wordsworth, BP ^{[1
]}

Brown, MA ^{[1
]}

机构：

[1] Univ Oxford, Botnar Res Ctr, Nuffield Orthopaed Ctr, Inst Musculoskeletal Sci, Oxford, England

来源：

GENES AND IMMUNITY | 2004年 / 5卷 / 03期

关键词：

major histocompatibility complex; rheumatoid arthritis; genetics;

D O I：

10.1038/sj.gene.6364045

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Rheumatoid arthritis is a common complex genetic disease, and, despite a significant genetic element, no gene other than HLA-DRB1 has been clearly demonstrated to be involved in the disease. However, this association accounts for less than half the overall genetic susceptibility. Investigation of other candidate genes, in particular those that reside within the major histocompatibility complex, are hampered by the presence of strong linkage disequilibrium and problems with study design.

引用

页码：151 / 157

页数：7

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