Joining Forces: A Call for Greater Collaboration to Study New Medicines in Children and Adolescents With Type 2 Diabetes

被引：22

作者：

Karres, Janina ^{[1
]}

Pratt, Valerie ^{[2
]}

Guettier, Jean-Marc ^{[2
]}

Temeck, Jean ^{[3
]}

Tamborlane, William V. ^{[4
]}

Dunger, David ^{[5
]}

Bejnariu, Cristina ^{[1
]}

De Beaufort, Carine ^{[6
]}

Tomasi, Paolo ^{[1
]}

机构：

[1] European Med Agcy, London, England

[2] US FDA, Div Metab & Endocrinol Prod, Silver Spring, MD USA

[3] US FDA, Off Pediat Therapeut, Silver Spring, MD USA

[4] Yale Univ, Sch Med, Ctr Clin Invest, New Haven, CT USA

[5] Univ Cambridge, Dept Paediat, Cambridge, England

[6] Univ Luxembourg, Ctr Syst Biomed, Esch Sur Alzette, Luxembourg

来源：

DIABETES CARE | 2014年 / 37卷 / 10期

基金：

英国医学研究理事会;

关键词：

TODAY CLINICAL-TRIAL; YOUTH; PREVALENCE; COHORT; CARE;

D O I：

10.2337/dc14-0494

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A collaborative effort will facilitate the collection of adequate and well-controlled pediatric efficacy and safety clinical trial data to inform pediatric use of new drugs to treat T2D. An approach relying on a multiarm trial is one particularly attractive approach that leverages efficiencies gained from use of a shared control group, with efficiencies gained from a shared research infrastructure. Success in pediatric drug development has often involved collaboration. Indeed, reliance on consortia-based approaches to evaluate novel therapies was successful for other relatively uncommon pediatric diseases (e.g., juvenile idiopathic arthritis and schizophrenia) and should be met with similar success in T2D. © 2014 by the American Diabetes Association.

引用

页码：2665 / 2667

页数：3

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