Chemiluminescent nitrogen detection for HPLC: An important new tool in organic analytical chemistry

被引：50

作者：

Fitch, WL ^{[1
]}

Szardenings, AK ^{[1
]}

Fujinari, EM ^{[1
]}

机构：

[1] ANTEK INSTRUMENTS,HOUSTON,TX 77090

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 10期

关键词：

D O I：

10.1016/S0040-4039(97)00191-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chemiluminescent nitrogen detection for HPLC is an important new high throughput technique for measuring yields and purities in synthetic organic chemistry. This destructive detector measures the total nitrogen content of a chromatographic peak, can be calibrated with any nitrogen containing compound, and thus allows quantitative analysis when authentic reference standards are not available. The application to solid phase synthesis is illustrated with a diketopiperazine synthesis. (C) 1997 Elsevier Science Ltd.

引用

页码：1689 / 1692

页数：4

共 35 条

[1] Combinatorial modification of natural products: Preparation of unencoded and encoded libraries of Rauwolfia alkaloids [J].

Atuegbu, A ;

Maclean, D ;

Nguyen, C ;

Gordon, EM ;

Jacobs, JW .

BIOORGANIC & MEDICINAL CHEMISTRY, 1996, 4 (07) :1097-1106

[2]

BENN SM, 1993, DEV FOOD SCI, V32, P65

[3]

Bizanek R, 1996, PEPTIDE RES, V9, P40

[4] THE COMBINATORIAL SYNTHESIS AND CHEMICAL AND BIOLOGICAL EVALUATION OF A 1,4-BENZODIAZEPINE LIBRARY [J].

BUNIN, BA ;

PLUNKETT, MJ ;

ELLMAN, JA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (11) :4708-4712

[5]

Dreux M., 1996, LC GC INTERNATIONAL, V9, P148

[6]

FITCH WL, 1997, ANN REPORTS COMBINAT, V1

[7]

Fujinari E.M., 1995, DEV FOOD SCI A, V37, P379, DOI [10.1016/S0167-4501(06)80167-6forsciint.2014.02.003, DOI 10.1016/S0167-4501(06)80167-6FORSCIINT.2014.02.003]

[8] Peptide content-determination of crude synthetic peptides by reversed-phase liquid chromatography and nitrogen-specific detection with a chemiluminescent nitrogen detector [J].

Fujinari, EM ;

Manes, JD ;

Bizanek, R .

JOURNAL OF CHROMATOGRAPHY A, 1996, 743 (01) :85-89

[9]

FUJINARI EM, 1993, DEV FOOD SCI, V32, P75

[10]

FUJINARI EM, 1993, DEV FOOD SCI, V33, P1033

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