Induction of quinone reductase activity by psoralidin isolated from Psoralea corylifolia in mouse hepa 1c1c7 cells

被引：24

作者：

Lee, Sung-Jin ^{[2
]}

Nam, Kung-Woo ^{[1
]}

Mar, Woongchon ^{[1
]}

机构：

[1] Seoul Natl Univ, Inst Nat Prod Res, Coll Pharm, Seoul 151742, South Korea

[2] Kangwon Natl Univ, Dept Anim Biotechnol, Chunchon 200701, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2009年 / 32卷 / 07期

关键词：

Quinone reductase; Chemoprevention; Hepa 1c1c7 cell line; ANTICARCINOGENIC ENZYME INDUCERS; INDUCED NEOPLASIA; NAD(P)H-QUINONE REDUCTASE; COLON CARCINOGENESIS; CANCER; INHIBITION; LIVER; OXIDOREDUCTASE; CHEMOPREVENTION; MUTAGENESIS;

D O I：

10.1007/s12272-009-1712-1

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Quinone reductase (QR) is a protective phase II enzyme against mutagens and carcinogens which is inducible by a number of chemical compounds in plants. This study was carried out to investigate effects of the fractions from the seeds of Psoralea corylifolia on the induction of QR with Hepa 1c1c7 murine hepatoma cell line. The ethyl acetate-soluble fraction of the methanolic extract from the seeds was found to induce QR and the concentration of 1.5 fold QR induction (1.5 FIC) was 1.2 mu g/mL. We obtained as an active compound, psoralidin, isolated from the ethyl acetate-soluble fraction after further sequential fractionation with column chromatography and 1.5 FIC of psoralidin was 0.5 mu g/mL. The seeds of Psoralea corylifolia and psoralidin might be a candidate for developing QR inducers.

引用

页码：1061 / 1065

页数：5

共 34 条

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