[1] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada
[2] Univ Toronto, Dept Med Genet, Toronto, ON M5S 1A8, Canada
[3] Univ Cambridge, Gurdon Inst, Cambridge CB2 1QN, England
[4] Canc Res UK, Mol & Populat Genet Lab, London WC2A 3PX, England
[5] Univ N Carolina, Sch Med, Dept Cell & Dev Biol, Chapel Hill, NC 27599 USA