How well do antidepressants work in older people? - A systematic review of Number Needed to Treat

被引:29
作者
Katona, C [1 ]
Livingston, G [1 ]
机构
[1] UCL Royal Free & Univ Coll Med Sch, Dept Psychiat & Behav Sci, London W1N 8AA, England
关键词
antidepressants; Number Needed to Treat older people; depression;
D O I
10.1016/S0165-0327(00)00332-3
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objectives: To make direct comparisons between studies of antidepressant treatment of older people using Number Needed to Treat (NNT) analysis. Methods: Medline and Embase Search 1966-1999 and contact with manufacturers of antidepressant drugs asking for any relevant data on file; NNT analyses of outcome in terms of efficacy and adverse effects. Results: Most antidepressant trials show efficacy; this is less clear for moclobemide and fluoxetine. Head-to-head comparisons between antidepressants showed significant superiority for paroxetine over fluoxetine and a trend in favour of SSRIs and venlafaxine over tricyclics. Conclusions: NNT analysis is one way of providing intelligible information on antidepressant efficacy and adverse effects which can inform clinical decisions. Limitations: Many studies do not present data in a form amenable to NNT analysis. Most head-to-head comparisons between antidepressants are underpowered. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:47 / 52
页数:6
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