The vaccinia virus I7L gene product is the core protein proteinase

被引：66

作者：

Byrd, CM

Bolken, TC

Hruby, DE

机构：

[1] SIGA Technol Inc, Corvallis, OR 97333 USA

[2] Oregon State Univ, Mol & Cellular Biol Program, Corvallis, OR 97331 USA

[3] Oregon State Univ, Dept Microbiol, Corvallis, OR 97331 USA

来源：

JOURNAL OF VIROLOGY | 2002年 / 76卷 / 17期

关键词：

D O I：

10.1128/JVI.76.17.8973-8976.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Maturation of vaccinia virus (W) core proteins is required for the production of infectious virions. The W G1L and I7L gene products are the leading candidates for the viral core protein proteinase (vCPP). Using transient-expression assays, data were obtained to demonstrate that the I7L gene product and its encoded cysteine proteinase activity are responsible for vCPP activity.

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页码：8973 / 8976

页数：4

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