Administration of antisense DNA for ghrelin causes an antidepressant and anxiolytic response in rats

被引：65

作者：

Kanehisa, Masayuki ^{[1
]}

Akiyoshi, Jotaro ^{[1
]}

Kitaichi, Tomoko ^{[1
]}

Matsushita, Hirotaka ^{[1
]}

Tanaka, Etsuhiro ^{[1
]}

Kodama, Kensuke ^{[1
]}

Hanada, Hiroaki ^{[1
]}

Isogawa, Koichi ^{[1
]}

机构：

[1] Oita Univ, Fac Med, Dept Neuropsychiat, Hasama Machi, Oita 8795593, Japan

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 2006年 / 30卷 / 08期

关键词：

ghrelin; antisense-DNA; antidepressant response; anxiolytic response; forced swimming test; anxiety; elevated plus maze test; black and white test; conditioned fear test;

D O I：

10.1016/j.pnpbp.2006.05.005

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Rationale: Ghrelin is a peptide of 28 amino acids found in mammals that increases the release of growth hormone, food intake, and body weight. Objectives: We investigated the relationship between ghrelin and the states of anxiety and depression by giving rats either antisense DNA for ghrelin, scrambled DNA or vehicle into the lateral ventricle of rats. Results: In forced swimming tests, rats that received antisense DNA decreased the length of time that they were immobile in the water. Ghrelin antisense oligonucleotides produced an anxiolytic-like effects in the elevated plus maze test, black and white test, or conditioned fear tests. Treatment with antisense DNA for ghrelin significantly decreased rat body weight. No significant effect on general locomotor activity was seen. Conclusions: These results suggest that administration of antisense DNA for ghrelin causes an antidepressant and anxiolytic response in rats. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：1403 / 1407

页数：5

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