Treatment of multiple sclerosis: recent trials and future perspectives

被引:51
作者
Noseworthy, JH
Gold, R
Hartung, HP
机构
[1] Karl Franzens Univ Graz, Dept Neurol, A-8036 Graz, Austria
[2] Mayo Clin & Mayo Fdn, Dept Neurol, Rochester, MN 55905 USA
[3] Univ Wurzburg, Dept Neurol, D-8700 Wurzburg, Germany
关键词
D O I
10.1097/00019052-199906000-00007
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
In the past year, further evidence establishing the usefulness of beta interferons and glatiramer in the treatment of relapsing-remitting multiple sclerosis has been advanced. Interferon-beta-1b was also shown to be efficacious in secondary progressive multiple sclerosis. This and other trials of symptomatic treatments are reviewed. Based on an appraisal of recent experimental studies, future promising approaches to intervene in the chain of immunopathogenetic events are discussed. (C) 1999 Lippincott Williams & Wilkins.
引用
收藏
页码:279 / 293
页数:15
相关论文
共 129 条
[1]   Intravenous immunoglobulin treatment in multiple sclerosis - Effect on relapses [J].
Achiron, A ;
Gabbay, U ;
Gilad, R ;
Hassin-Baer, S ;
Barak, Y ;
Gornish, M ;
Elizur, A ;
Goldhammer, Y ;
Sarova-Pinhas, I .
NEUROLOGY, 1998, 50 (02) :398-402
[2]   Copolymer 1 acts against the immunodominant epitope 82-100 of myelin basic protein by T cell receptor antagonism in addition to major histocompatibility complex blocking [J].
Aharoni, R ;
Teitelbaum, D ;
Arnon, R ;
Sela, M .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (02) :634-639
[3]   Tremor in multiple sclerosis [J].
Alusi, SH ;
Glickman, S ;
Aziz, TZ ;
Bain, PG .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1999, 66 (02) :131-134
[4]  
[Anonymous], 1991, Lancet, V337, P441
[5]   Role of the leukocyte-adhesion molecule L-selectin in experimental autoimmune encephalomyelitis [J].
Archelos, JJ ;
Jung, S ;
Rinner, W ;
Lassmann, H ;
Miyasaka, M ;
Hartung, HP .
JOURNAL OF THE NEUROLOGICAL SCIENCES, 1998, 159 (02) :127-134
[6]   INHIBITION OF EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS BY AN ANTIBODY TO THE INTERCELLULAR-ADHESION MOLECULE ICAM-1 [J].
ARCHELOS, JJ ;
JUNG, S ;
MAURER, M ;
SCHMIED, M ;
LASSMANN, H ;
TAMATANI, T ;
MIYASAKA, M ;
TOYKA, KV ;
HARTUNG, HP .
ANNALS OF NEUROLOGY, 1993, 34 (02) :145-154
[7]   The role of adhesion molecules in multiple sclerosis: biology, pathogenesis and therapeutic implications [J].
Archelos, JJ ;
Hartung, HP .
MOLECULAR MEDICINE TODAY, 1997, 3 (07) :310-321
[8]  
Arima T, 1996, J IMMUNOL, V156, P4916
[9]   Oral or intravenous methylprednisolone for acute relapses of MS? [J].
Barkhof, F ;
Polman, C .
LANCET, 1997, 349 (9056) :893-894
[10]   Randomised trial of oral and intravenous methylprednisolone in acute relapses of multiple sclerosis [J].
Barnes, D ;
Hughes, RAC ;
Morris, RW ;
WadeJones, O ;
Brown, P ;
Britton, T ;
Francis, DA ;
Perkin, GD ;
Rudge, P ;
Swash, M ;
Katifi, H ;
Farmer, S ;
Frankel, J .
LANCET, 1997, 349 (9056) :902-906