Genome sequence of the radioresistant bacterium Deinococcus radiodurans R1

被引:777
作者
White, O
Eisen, JA
Heidelberg, JF
Hickey, EK
Peterson, JD
Dodson, RJ
Haft, DH
Gwinn, ML
Nelson, WC
Richardson, DL
Moffat, KS
Qin, HY
Jiang, LX
Pamphile, W
Crosby, M
Shen, M
Vamathevan, JJ
Lam, P
McDonald, L
Utterback, T
Zalewski, C
Makarova, KS
Aravind, L
Daly, MJ
Minton, KW
Fleischmann, RD
Ketchum, KA
Nelson, KE
Salzberg, S
Smith, HO
Venter, JC
Fraser, CM
机构
[1] Inst Genome Res, Rockville, MD 20850 USA
[2] Natl Lib Med, Natl Ctr Biotechnol Informat, Bethesda, MD 20894 USA
[3] Uniformed Serv Univ Hlth Sci, Dept Pathol, Bethesda, MD 20814 USA
关键词
D O I
10.1126/science.286.5444.1571
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The complete genome sequence of the radiation-resistant bacterium Deinococcus radiodurans R1 is composed of two chromosomes (2,648,638 and 412,348 base pairs), a megaplasmid (172,466 base pairs), and a small plasmid (45,704 base pairs), yielding a total genome of 3,284,156 base pairs. Multiple components distributed on the chromosomes and megaplasmid that contribute to the ability of D. radiodurans to survive under conditions of starvation, oxidative stress, and high amounts of DNA damage were identified. Deinococcus radiodurans represents an organism in which all systems for DNA repair, DNA damage export, desiccation and starvation recovery, and genetic redundancy are present in one cell.
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页码:1571 / 1577
页数:7
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