Dynamic kinetic resolution of epichlorohydrin via enantioselective catalytic ring opening with TMSN(3). Practical synthesis of aryl oxazolidinone antibacterial agents

被引：60

作者：

Schaus, SE ^{[1
]}

Jacobsen, EN ^{[1
]}

机构：

[1] HARVARD UNIV,DEPT CHEM & CHEM BIOL,CAMBRIDGE,MA 02138

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 44期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0040-4039(96)01835-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The dynamic kinetic resolution of racemic epichlorohydrin has been achieved via enantioselective asymmetric ring opening with TMSN(3) catalyzed by the (salen)Cr(III)N-3 complex 1. The resulting 3-azido-1-chloro-2-trimethylsiloxypropane product was obtained in high enantiomeric purity and incorporated into the synthesis of U-100592, a representative from a class of highly-promising aryl oxazolidinone antibacterial agents. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：7937 / 7940

页数：4

共 6 条

[1] Identification of a novel oxazolidinone (U-100480) with potent antimycobacterial activity [J].