Activity-dependent synaptogenesis in the adult mammalian cortex

被引：103

作者：

Zito, K ^{[1
]}

Svoboda, K ^{[1
]}

机构：

[1] Cold Spring Harbor Lab, Howard Hughes Med Inst, Cold Spring Harbor, NY 11724 USA

来源：

NEURON | 2002年 / 35卷 / 06期

关键词：

D O I：

10.1016/S0896-6273(02)00903-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recent electron microscopic studies provide evidence that the adult cortex generates new synapses in response to sensory activity and that these structural changes can occur rapidly, within 24 hr of sensory stimulation. Together with progress imaging synapses in vivo, the stage appears set for advances in understanding the dynamics and mechanisms of experience-dependent synaptogenesis.

引用

页码：1015 / 1017

页数：3

共 14 条

[1] STRUCTURAL-CHANGES ACCOMPANYING MEMORY STORAGE [J].

BAILEY, CH ;

KANDEL, ER .

ANNUAL REVIEW OF PHYSIOLOGY, 1993, 55 :397-426

[2]

Barth AL, 2000, J NEUROSCI, V20, P4206

[3] Cortical plasticity: From synapses to maps [J].

Buonomano, DV ;

Merzenich, MM .

ANNUAL REVIEW OF NEUROSCIENCE, 1998, 21 :149-186

[4]

Dailey ME, 1996, J NEUROSCI, V16, P2983

[5] Anatomical pathways and molecular mechanisms for plasticity in the barrel cortex [J].

Fox, K .

NEUROSCIENCE, 2002, 111 (04) :799-814

[6] Adult cortical dynamics [J].

Gilbert, CD .

PHYSIOLOGICAL REVIEWS, 1998, 78 (02) :467-485

[7] BDNF regulates the maturation of inhibition and the critical period of plasticity in mouse visual cortex [J].

Huang, ZJ ;

Kirkwood, A ;

Pizzorusso, T ;

Porciatti, V ;

Morales, B ;

Bear, MF ;

Maffei, L ;

Tonegawa, S .

CELL, 1999, 98 (06) :739-755

[8]

Kleim JA, 1996, J NEUROSCI, V16, P4529

[9] Formation of dendritic spines with GABAergic synapses by whisker stimulation in induced adult mice [J].

Knott, GW ;

Quairiaux, C ;

Genoud, C ;

Welker, E .

NEURON, 2002, 34 (02) :265-273

[10] Experience-dependent plasticity of dendritic spines in the developing rat barrel cortex in vivo [J].

Lendvai, B ;

Stern, EA ;

Chen, B ;

Svoboda, K .

NATURE, 2000, 404 (6780) :876-881

← 1 2 →