Metabolically Healthy Obesity-Does it Exist?

被引：62

作者：

Boonchaya-Anant, Patchaya ^{[1
,2
,3
]}

Apovian, Caroline M. ^{[1
]}

机构：

[1] Boston Univ, Sect Endocrinol Diabet & Nutr, Dept Med, Sch Med,Boston Med Ctr, Boston, MA 02118 USA

[2] Chulalongkorn Univ, Fac Med, Endocrinol & Metab Unit, Dept Med, Bangkok 10330, Thailand

[3] King Chulalongkorn Mem Hosp, Thai Red Cross Soc, Bangkok 10330, Thailand

来源：

CURRENT ATHEROSCLEROSIS REPORTS | 2014年 / 16卷 / 10期

关键词：

Metabolically healthy obese; Insulin resistance; Adipose tissue inflammation; ADIPOSE-TISSUE INFLAMMATION; REGULATORY T-CELLS; C-REACTIVE PROTEIN; BODY-MASS INDEX; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; MACROPHAGE INFILTRATION; GENE-EXPRESSION; NORMAL-WEIGHT; ALL-CAUSE;

D O I：

10.1007/s11883-014-0441-1

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

The prevalence of obesity has been increasing worldwide over the past 30 years and is a major public health concern. Obesity is known to be associated with metabolic disturbances including insulin resistance and inflammation; however, there is a subset of obese subjects who have normal metabolic profiles, and they have been identified as the metabolically healthy obese (MHO). Several studies have described MHO as obese individuals who have high levels of insulin sensitivity and the absence of diabetes, dyslipidemia, or hypertension. The prevalence of MHO varies from 20 to 30 % among obese individuals. This review will discuss the MHO phenotype; the differences between MHO and metabolically unhealthy obese (MUO) individuals; and the possible underlying mechanisms including adipocyte differentiation, immune regulation, and cellular energy metabolism.

引用

页数：9

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