Total synthesis of (-)-callystatin A

被引：61

作者：

Langille, NF

Panek, JS

机构：

[1] Boston Univ, Dept Chem, Boston, MA 02215 USA

[2] Boston Univ, Ctr Chem Methodol & Library Dev, Metcalf Ctr Sci & Engn, Boston, MA 02215 USA

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 18期

关键词：

D O I：

10.1021/ol048664r

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convergent enantioselective synthesis of the natural product (-)-callystatin A (1) is described. Key features of the synthesis include a lipase-mediated kinetic resolution to install the C5 lactone stereochemistry, a hydrozirconation-based approach to the C8-C9 trisubstituted (Z)-olefin, and a stereoselective cross-coupling of a vinyl dibromide to install the C14-C15 trisubstituted (E)-olefin.

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页码：3203 / 3206

页数：4

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