Puraquinonic acid, a novel inducer of differentiation of human HL-60 promyelocytic leukemia cells from Mycena pura (pers ex fr)

被引:20
作者
Becker, U
Erkel, G
Anke, T
Sterner, O
机构
[1] UNIV KAISERSLAUTERN,LEHRSTUHL BIOTECHNOL,D-67663 KAISERSLAUTERN,GERMANY
[2] LUND UNIV,DIV ORGAN CHEM 2,S-22100 LUND,SWEDEN
来源
NATURAL PRODUCT LETTERS | 1997年 / 9卷 / 03期
关键词
Basidiomycete; Mycena pura; differentiation inducer; puraquinonic acid; strobilurin D;
D O I
10.1080/10575639708048319
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The novel norilludalane sesquiterpene puraquinonic acid was isolated from mycelial cultures of the basidiomycete Mycena pura as an inducer of morphological and physiological differentiation of mammalian cells. It induces the differentiation of 30-40 % of HL-60 cells into granulocyte- or monocyte/macrophage-like cells at 380 mu M. At the same concentration, U-937 cells, which are blocked at a later stage of development, are affected to a much lesser extent. In addition to puraquinonic acid, strobilurin D, and antifungal metabolite previously reported from Cyphellopsis anomala, was also isolated.
引用
收藏
页码:229 / 236
页数:8
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