Dopamine, learning and motivation

被引：2336

作者：

Wise, RA ^{[1
]}

机构：

[1] NIDA, Behav Neurosci Branch, Intramural Res Program, NIH, Bethesda, MD 20892 USA

来源：

NATURE REVIEWS NEUROSCIENCE | 2004年 / 5卷 / 06期

关键词：

D O I：

10.1038/nrn1406

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The hypothesis that dopamine is important for reward has been proposed in a number of forms, each of which has been challenged. Normally, rewarding stimuli such as food, water, lateral hypothalamic brain stimulation and several drugs of abuse become ineffective as rewards in animals given performance-sparing doses of dopamine antagonists. Dopamine release in the nucleus accumbens has been linked to the efficacy of these unconditioned rewards, but dopamine release in a broader range of structures is implicated in the 'stamping-in' of memory that attaches motivational importance to otherwise neutral environmental stimuli.

引用

页码：483 / 494

页数：12

共 198 条

[1] Nucleus accumbens dopamine depletions make rats more sensitive to high ratio requirements but do not impair primary food reinforcement [J].

Aberman, JE ;

Salamone, JD .

NEUROSCIENCE, 1999, 92 (02) :545-552

[2] STRIATAL REGULATION OF MORPHINE-INDUCED HYPERPHAGIA - AN ANATOMICAL MAPPING STUDY [J].

BAKSHI, VP ;

KELLEY, AE .

PSYCHOPHARMACOLOGY, 1993, 111 (02) :207-214

[3] INSTRUMENTAL PERFORMANCE FOLLOWING A SHIFT IN PRIMARY MOTIVATION DEPENDS ON INCENTIVE LEARNING [J].

BALLEINE, B .

JOURNAL OF EXPERIMENTAL PSYCHOLOGY-ANIMAL BEHAVIOR PROCESSES, 1992, 18 (03) :236-250

[4] DRUGS AFFECTING MOVEMENT DISORDERS [J].

BARBEAU, A .

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1974, 14 :91-113

[5] NEUROBIOLOGY OF MOTIVATION - DOUBLE DISSOCIATION OF 2 MOTIVATIONAL MECHANISMS MEDIATING OPIATE REWARD IN DRUG-NAIVE VERSUS DRUG-DEPENDENT ANIMALS [J].

BECHARA, A ;

HARRINGTON, F ;

NADER, K ;

VANDERKOOY, D .

BEHAVIORAL NEUROSCIENCE, 1992, 106 (05) :798-807

[6] THE ROLE OF DOPAMINE IN LOCOMOTOR-ACTIVITY AND LEARNING [J].

BENINGER, RJ .

BRAIN RESEARCH REVIEWS, 1983, 6 (02) :173-196

[7] What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? [J].

Berridge, KC ;

Robinson, TE .

BRAIN RESEARCH REVIEWS, 1998, 28 (03) :309-369

[8] Parsing reward [J].

Berridge, KC ;

Robinson, TE .

TRENDS IN NEUROSCIENCES, 2003, 26 (09) :507-513

[9] THE MIND OF AN ADDICTED BRAIN - NEURAL SENSITIZATION OF WANTING VERSUS LIKING [J].

BERRIDGE, KC ;

ROBINSON, TE .

CURRENT DIRECTIONS IN PSYCHOLOGICAL SCIENCE, 1995, 4 (03) :71-76

[10] Measuring hedonic impact in animals and infants: microstructure of affective taste reactivity patterns [J].

Berridge, KC .

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2000, 24 (02) :173-198

← 1 2 3 4 5 6 7 8 9 10 →