CpG island methylation pattern in different human tissues and its correlation with gene expression

被引：108

作者：

Fan, Shicai ^{[1
,2
,3
]}

Zhang, Xuegong ^{[2
,3
]}

机构：

[1] Univ Elect Sci & Technol China, Sch Automat Engn, Chengdu 610054, Peoples R China

[2] Tsinghua Univ, MOE Key Lab Bioinformat, Beijing 100084, Peoples R China

[3] Tsinghua Univ, Bioinformat Div, TNLIST Dept Automat, Beijing 100084, Peoples R China

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2009年 / 383卷 / 04期

关键词：

DNA methylation; CpG island; Methylation pattern; Gene expression; DNA METHYLATION; HUMAN GENOME; MARKERS; WIDE; HYPERMETHYLATION; MOUSE;

D O I：

10.1016/j.bbrc.2009.04.023

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The study on DNA methylation pattern in different human tissues attracts increasing interest nowadays, but a systematic analysis of CpG island methylation pattern between both somatic tissues and gametocyte is still lacking. In this work, we analyzed the CpG island methylation data of sperm and other 11 somatic tissues from Human Epigenome Project, and found that the CpG island methylation profiles are highly correlated between Somatic tissues, while the methylation profile in sperm is quite distinct. Furthermore, we observed that in the six tissues investigated, there is no obvious correlation between the methylation level of promoter CpG islands and corresponding gene expression across different tissues. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：421 / 425

页数：5

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