Polymorphism of NACP-Rep1 in Parkinson's disease: An etiologic link with essential tremor?

被引：96

作者：

Tan, EK

Matsuura, T

Nagamitsu, S

Khajavi, M

Jankovic, J

Ashizawa, T

机构：

[1] Baylor Coll Med, Dept Neurol, Houston, TX 77030 USA

[2] Vet Affairs Med Ctr, Serv Neurol, Houston, TX 77030 USA

来源：

NEUROLOGY | 2000年 / 54卷 / 05期

关键词：

PD; essential tremor; NACP; Rep1; polymorphism;

D O I：

10.1212/WNL.54.5.1195

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

An allele (263bp) of the nonamyloid component of plaques (NACP)-Rep1 polymorphism has shown association with sporadic PD in a German population. The authors studied this polymorphism in 100 American PD patients and 100 healthy controls. The authors also studied 46 essential tremor (ET) and 55 Huntington's disease (HD) patients. Allele 263bp was significantly higher in PD patients (OR = 3.86) and ET patients (OR = 6.42) but not HD patients, compared with healthy controls. The association of allele 263bp with PD and ET suggests a possible etiologic link between these two conditions.

引用

页码：1195 / 1198

页数：4

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