A novel synthesis of (+)-duocarmycin SA

被引：15

作者：

Fukuda, Y ^{[1
]}

Terashima, S ^{[1
]}

机构：

[1] SAGAMI CHEM RES CTR,SAGAMIHARA,KANAGAWA 229,JAPAN

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 41期

关键词：

D O I：

10.1016/S0040-4039(97)01716-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The title synthesis was achieved in eight steps from (S)-5-aminoindoline (S)-4 by a method featuring sequential dehydrogenation, double bond isomerization, and oxidative cyclization of (S)-5-[(1-methoxycarbonylethyl)amino]indoline 5 as the key steps. The sequential reaction was effected by using MnO2-Pd(OAc)(2) as the oxidizing agent in the presence of an acid catalyst. (C) 1997 Elsevier Science Ltd.

引用

页码：7207 / 7208

页数：2

共 18 条

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