Of mice and (mad) cows: Transgenic mice help to understand prions

被引：12

作者：

Gabizon, R ^{[1
]}

Taraboulos, A ^{[1
]}

机构：

[1] HEBREW UNIV JERUSALEM, HADASSAH MED SCH, DEPT MOL BIOL, IL-91010 JERUSALEM, ISRAEL

来源：

TRENDS IN GENETICS | 1997年 / 13卷 / 07期

关键词：

D O I：

10.1016/S0168-9525(97)01116-5

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Prions present a most fascinating biological conundrum. These proteinaceous particles seem to propagate through a chain reaction in which a host protein, PrPC, is post-translationally misfolded to form new prions. By this mechanism they 'replicate' without involvement of specific nucleic acids. Due to their unique modus operandi, prions cause disorders tat can be infectious, inherited and sporadic. Transgenetics has been invaluable in helping to understand this unique phenomenon. Here we describe some of the most salient contributions of transgenic mice to this field.

引用

页码：264 / 269

页数：6

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