T Lymphocyte Maturation Is Impaired in Healthy Young Individuals Carrying Trisomy 21 (Down Syndrome)

被引：35

作者：

Guazzarotti, Laura ^{[1
]}

Trabattoni, Daria ^{[2
]}

Castelletti, Eleonora ^{[2
]}

Boldrighini, Benedetta ^{[2
]}

Piacentini, Luca ^{[2
]}

Duca, Piergiorgio ^{[2
]}

Beretta, Silvia ^{[2
]}

Pacei, Michela ^{[2
]}

Caprio, Cristiana ^{[2
]}

Vigano, Alessandra ^{[2
]}

di Natale, Berardo ^{[2
]}

Zuccotti, Gian Vincenzo ^{[2
]}

Clerici, Mario ^{[2
]}

机构：

[1] Luigi Sacco Hosp, Dept Pediat, I-20157 Milan, Italy

[2] Univ Milan, Milan, Italy

来源：

AJIDD-AMERICAN JOURNAL ON INTELLECTUAL AND DEVELOPMENTAL DISABILITIES | 2009年 / 114卷 / 02期

关键词：

CELL SUBSETS; MEMORY; DIFFERENTIATION; INTERLEUKIN-7; EXPRESSION; CHILDREN; BLOOD; IL-7; IMMUNODEFICIENCY; OVEREXPRESSION;

D O I：

10.1352/2009.114.100-109

中图分类号：

G76 [特殊教育];

学科分类号：

040109 ;

摘要：

Cytokine production, immune activation, T lymphocytes maturation, and serum IL-7 concentration were examined in 24 youngsters with Down syndrome and no acquired diseases (healthy Down syndrome [12 prepubertal, 13 pubertal]) and 42 age- and gender-matched controls (20 prepubertal, 22 pubertal). Results showed that a complex immune and impairment is present in healthy individuals with Down syndrome in whom interferon gamma, interleukin (IL) IL-10 production, as well as serum IL-7 concentrations and activation markers-bearing T lymphocytes were significantly augmented. Additionally, a complex skewing of post-thymic lymphocyte maturation pathways was observed in patients: significant reduction of CD4+ and CD8+ naive (RA+CCR7+) lymphocytes, significant increase of CD4+ and CD8+ central memory (RA-CCR7+), and terminally differentiated (TD) (RA+CCR7-) lymphocytes.

引用

页码：100 / 109

页数：10

共 46 条

[1] Role of interleukin-7 in T-cell development from hematopoietic stem cells [J].

Akashi, K ;

Kondo, M ;

Weissman, IL .

IMMUNOLOGICAL REVIEWS, 1998, 165 :13-28

[2] Memory lanes [J].

Badovinac, VP ;

Harty, JT .

NATURE IMMUNOLOGY, 2003, 4 (03) :212-213

[3] IMBALANCE OF THE CD4+ SUBPOPULATIONS EXPRESSING CD45RA AND CD29 ANTIGENS IN THE PERIPHERAL-BLOOD OF ADULTS AND CHILDREN WITH DOWN-SYNDROME [J].

BARRENA, MJ ;

ECHANIZ, P ;

GARCIASERRANO, C ;

CUADRADO, E .

SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1993, 38 (04) :323-326

[4]

BERTOTTO A, 1984, THYMUS, V6, P365

[5]

BIASIN M, 2000, CELLULAR ASPECTS HIV, P155

[6] Increased interleukin-7 plasma levels are associated with recovery of CD4+T cells in HIV-infected children [J].

Correa, R ;

Resino, S ;

Muñoz-Fernández, MA .

JOURNAL OF CLINICAL IMMUNOLOGY, 2003, 23 (05) :401-406

[7]

COSSARIZZA A, 1991, BLOOD, V77, P1263

[8]

COSSARIZZA A, 1990, AM J MED GENET, P213

[9] Immune dysfunction in Down's syndrome: Primary immune deficiency or early senescence of the immune system? [J].

Cuadrado, E ;

Barrena, MJ .

CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 1996, 78 (03) :209-214

[10] Intrinsic abnormalities of lymphocyte counts in children with Down syndrome [J].

De Hingh, YCM ;

Van Der Vossen, PW ;

Gemen, EFA ;

Mulder, AB ;

Hop, WCJ ;

Brus, F ;

De Vries, E .

JOURNAL OF PEDIATRICS, 2005, 147 (06) :744-747

← 1 2 3 4 5 →