Rapid analogue synthesis of trisubstituted triazolo[4,3-b]pyridazines

被引：19

作者：

Collins, I ^{[1
]}

Castro, JL ^{[1
]}

Street, LJ ^{[1
]}

机构：

[1] Merck Sharp & Dohme Ltd, Res Labs, Dept Med Chem, Ctr Res Neurosci, Harlow CM20 2QR, Essex, England

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 05期

关键词：

pyridazines; triazoles; coupling reactions; silicon; silicon compounds;

D O I：

10.1016/S0040-4039(99)02153-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A rapid analogue synthesis of biologically active 3,6,7-trisubstituted 1,2,4-triazolo[4,3-b]pyridazines was devised to give easy and selective variation of the three substituents through combinations of silicon-directed anion formation, palladium-catalysed couplings and SNAr displacements. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：781 / 784

页数：4

共 20 条

[1]

COLVIN EW, 1988, SILICON REAGENTS ORG, P39

[2]

CORRIU RJP, 1991, SILICON HETEROATOM B, P1

[3]

DONDONI A, 1987, SYNTHESIS-STUTTGART, P693

[4] LARGE RATE ACCELERATIONS IN THE STILLE REACTION WITH TRI-2-FURYLPHOSPHINE AND TRIPHENYLARSINE AS PALLADIUM LIGANDS - MECHANISTIC AND SYNTHETIC IMPLICATIONS [J].